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Archived from the original on 14 September 2016. Paralysie des mouvements associés des yeux. "Sunset eye sign | Radiology Reference Article | ". Paediatrics: A Core Text on Child Health, Second Edition. ^ Waterston, Tony Helms, Peter Ward-Platt, Martin ().Neurologic Complications of Cancer Therapy. ^ MPH, Eudocia Quant Lee, MD MD, David Schiff MD, Patrick Y.A Dictionary of Neurological Signs: Clinical Neurosemiology. However, rapid resolution after normalization of intracranial pressure following placement of a ventriculoperitoneal shunt has been reported. The eye findings of Parinaud's syndrome generally improve slowly over months, especially with resolution of the causative factor continued resolution after the first 3–6 months of onset is uncommon. Retraction nystagmus and convergence movement are usually improved with this procedure as well. Visually significant upgaze palsy can be relieved with bilateral inferior rectus recessions. A thorough workup, including neuroimaging is essential to rule out anatomic lesions or other causes of this syndrome. Treatment is primarily directed towards etiology of the dorsal midbrain syndrome. Confirmation can be made via imaging, such as CT scan or MRI. Vertical supranuclear ophthalmoplegia has also been associated with metabolic disorders, such as Niemann-Pick disease, Wilson's disease, kernicterus, and barbiturate overdose.ĭiagnosis can be made via combination of physical exam, particularly deficits of the relevant cranial nerves. Neoplasms and giant aneurysms of the posterior fossa have also been associated with the midbrain syndrome. However, any other compression, ischemia or damage to this region can produce these phenomena: obstructive hydrocephalus, midbrain hemorrhage, cerebral arteriovenous malformation, trauma and brainstem toxoplasmosis infection. Older patients following stroke of the upper brainstem.Women in their 20s-30s with multiple sclerosis.Young patients with brain tumors in the pineal gland or midbrain: pinealoma ( intracranial germinomas) are the most common lesion producing this syndrome.Specifically, compression or ischemic damage of the mesencephalic tectum, including the superior colliculus adjacent oculomotor (origin of cranial nerve III) and Edinger-Westphal nuclei, causing dysfunction to the motor function of the eye.Ĭlassically, it has been associated with three major groups: Parinaud's syndrome results from injury, either direct or compressive, to the dorsal midbrain. The area affected in Parinaud's syndrome is indicated by the striped region. It has less commonly been associated with spasm of accommodation on attempted upward gaze, pseudoabducens palsy (also known as thalamic esotropia) or slower movements of the abducting eye than the adducting eye during horizontal saccades, see-saw nystagmus and associated ocular motility deficits including skew deviation, oculomotor nerve palsy, trochlear nerve palsy and internuclear ophthalmoplegia.Ĭross section of midbrain. It is also commonly associated with bilateral papilledema. Neurosurgeons see this sign most commonly in patients with failed hydrocephalus shunts. Conjugate down gaze in the primary position: "setting-sun sign".The easiest way to bring out this reaction is to ask the patient to follow down-going stripes on an optokinetic drum. On fast up-gaze, the eyes pull in and the globes retract. Convergence-retraction nystagmus: Attempts at upward gaze often produce this phenomenon.Pseudo- Argyll Robertson pupils: Accommodative paresis ensues, and pupils become mid-dilated and show light-near dissociation.This vertical palsy is supranuclear, so doll's head maneuver should elevate the eyes, but eventually all upward gaze mechanisms fail. Paralysis of upwards gaze: Downward gaze is usually preserved.Parinaud's syndrome is a cluster of abnormalities of eye movement and pupil dysfunction, characterized by: